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Proteintech HumanKine™ recombinant human IGF-I protein

HumanKine™ recombinant protein

Additional Details:
Additional Details: Weight: 0.00010kg



Product Code. 17680087

Quantity Price
1 £ 133.0 / 1000µg
In stock, ready to ship: 2
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Description and Specification

Specification

Accession Number P05019
Formulation 1 x PBS pH 7.4
Gene ID (Entrez) 3479
Molecular Weight (g/mol) 10 kDa
Quantity 1000 μg
Source HEK293
Storage Requirements Lyophilized product should be stored at -20°C to -80°C until expiry date and (at Room Temperature for 2 weeks.)
Endotoxin Concentration <1 EU/μg
Specific Reactivity Human
Recombinant Recombinant
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1 xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).
Activity 2-14 ng/mL EC50
Form Lyophilized
Purity or Quality Grade >95%

The Insulin like growth factor-1, also known as Somatomedin-C is a growth factor which is structurally related to insulin and is an important regulator of growth and differentiation in various tissues and cell systems. Human IGF-1 is synthesized as two precursor isoforms with N- and alternate C-terminal propeptide. The two precursor isoforms are differentially expressed by various tissues. The proteolytic cleavage of the N- and C-terminal regions results in the mature IGF-1 protein which is identical between isoforms. IGF-1 binds to IGF-1 receptor and induces receptor autophosphorylation. This further phosphorylates Insulin receptor substrate -1 (IRS-1) and activates various downstream signaling pathways including the PI3-AKT, MAPK etc. (PMID: 17354613, 17113337, 29535161)